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  • GENE_NAME : CD1C

    CD_NAME : CD1c

    DESC: CD1C antigen; c polypeptide
    OTH_NAMES: CD1
    CLONE_NAME ISO_TYPE SUBMITTER AVAILABLE_FROM
    L161 IgG1  Bernard  AbD Serotec
    L161 IgG1 Bernard  BioLegend
  • CLONE_NAME ISO_TYPE SUBMITTER AVAILABLE_FROM
    7C6 IgM  Knapp 
    10C3 unknown  Knapp 
    AD5-8E7 IgG2a Winkels
    49.3 IgG Imanishi
    L7 IgG2a  Kikuchi 
    L161 IgG1  Bernard  AbD Serotec
    M241 IgG1  Knowles 
    PHM3 IgG2a  Kraft 
    L161 IgG1 Bernard  BioLegend
  • STRUCTURE


    CD1c is a non-polimorphic type 1 integral glycoprotein with a similar structure to MHC class I molecules. CD1c is composed of a short cytoplasmic tail, a transmembrane domain and an extracellular region that contains 3 α domains.1-2 The α1 and α2 bind to the ligand.2 The α3 domain interacts with β-2 microglobulin, forming a heterodimer. 2 The cytoplasmic tail contains a tyrosine-based motif for adaptors binding. 2

    1. Kaczmarek R, Pasciak M, Szymczak-Kulus K, Czerwinski M. CD1: A Singed Cat of the Three Antigen Presentation Systems. Arch Immunol Ther Exp. 2017;65:201-214.

    2. Zajonc DM. The CD1 family: serving lipid antigens to T cells since the Mesozoic era. Immunogenetics. 2016;68:561-76.

  • LIGANDS


    Extracellular

    CD1c ligands include isoprenoid glycolipids1, phosphatidylcholines2, glycerophospholipids2, sphingomyelin2, sulfatide3, phosphomycoketide lipids4-5, N-terminally acylated lipopeptides and the TCR. 6-7 It interacts with β-2 microglobulin in cis.8

    Intracellular associate molecules

    CD1c can be associated with AP-3.9

    1. Moody DB, Ulrichs T, Mühlecker W, Young DC, Gurcha SS, Grant E, Rosat JP, Brenner MB, Costello CE, Besra GS, Porcelli SA. CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection. Nature. 2000;404:884-8.

    2. Haig NA, Guan Z, Li D, McMichael A, Raetz CR, Xu XN. Identification of self-lipids presented by CD1c and CD1d proteins. J Biol Chem. 2011;286:37692-701.

    3. Shamshiev A, Gober HJ, Donda A, Mazorra Z, Mori L, De Libero G. Presentation of the same glycolipid by different CD1 molecules. J Exp Med. 2002;195:1013-21.

    4. Scharf L, Li NS, Hawk AJ, Garzón D, Zhang T, Fox LM, Kazen AR, Shah S, Haddadian EJ, Gumperz JE, Saghatelian A, Faraldo-Gómez JD, Meredith SC, Piccirilli JA, Adams EJ. The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation. Immunity. 2010;33:853-62.

    5. Ly D, Kasmar AG, Cheng TY, de Jong A, Huang S, Roy S, Bhatt A, van Summeren RP, Altman JD, Jacobs WR Jr, Adams EJ, Minnaard AJ, Porcelli SA, Moody DB. CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens. J Exp Med. 2013;210:729-41.

    6. Van Rhijn I, Young DC, De Jong A, Vazquez J, Cheng TY, Talekar R, Barral DC, León L, Brenner MB, Katz JT, Riese R, Ruprecht RM, O'Connor PB, Costello CE, Porcelli SA, Briken V, Moody DB. CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids. J Exp Med. 2009;206:1409-22.

    7. Roy S, Ly D, Li NS, Altman JD, Piccirilli JA, Moody DB, Adams EJ. Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by αβ T cells. Proc Natl Acad Sci U S A. 2014;111:E4648-57.

    8. Zajonc DM. The CD1 family: serving lipid antigens to T cells since the Mesozoic era. Immunogenetics. 2016;68:561-76.

    9. Van Rhijn I, Ly D, Moody DB. CD1a, CD1b, and CD1c in immunity against mycobacteria. Adv Exp Med Biol. 2013;783:181-97.


  • GENE_NAME : CD1C

    CD_NAME : CD1c

    CD1c is expressed on thymocytes, monocytes and dendritic cells, including epidermal Langerhans cells, interdigitating and dermal dendritic cells. 1-3 In addition, CD1c is also present in germinal center, mantle zone and splenic marginal zone B cells, but also in a subset of circulating B cells.1,4

    1. Dougan SK, Kaser A, Blumberg RS. CD1 expression on antigen-presenting cells. Curr Top Microbiol Immunol. 2007;314:113-41.

    2. Reinink P, Van Rhijn I. Mammalian CD1 and MR1 genes. Immunogenetics. 2016;68:515-23.

    3. Schrøder M, Melum GR, Landsverk OJ, Bujko A, Yaqub S, Gran E, Aamodt H, Bækkevold ES, Jahnsen FL, Richter L. CD1c-Expression by Monocytes - implications for the Use of Commercial CD1c+ Dendritic Cell Isolation Kits. PLoS One. 2016;11:e0157387.

    4. Adams EJ. Diverse antigen presentation by the Group 1 CD1 molecule, CD1c. Mol Immunol. 2013;55:182-5.


  • GENE_NAME : CD1C

    CD_NAME : CD1c

    CD1c, as other members of the CD1 family, is involved in the immune response by presenting self and non-self lipids and glycolipid antigens to T cells TCR-αβ and T cells TCR-γδ. For instance, CD1c presents lipids from bacteria such as Mycobacterium tuberculosis and M. avium. 1

    1. Adams EJ. Diverse antigen presentation by the Group 1 CD1 molecule, CD1c. Mol Immunol. 2013;55:182-5.


  • GENE_NAME : CD1C

    CD_NAME : CD1c

    Cell marker

    CD1c can be used as a marker of CD14- dendritic cells, CD14+ monocytes and splenic marginal zone B cells.1-3

    1. Collin M, McGovern N, Haniffa M. Human dendritic cell subsets. Immunology. 2013;140:22-30.

    2. Schrøder M, Melum GR, Landsverk OJ, Bujko A, Yaqub S, Gran E, Aamodt H, Bækkevold ES, Jahnsen FL, Richter L. CD1c-Expression by Monocytes - Implications for the Use of Commercial CD1c+ Dendritic Cell Isolation Kits. PLoS One. 2016;11:e0157387.

    3. Weller S, Braun MC, Tan BK, Rosenwald A, Cordier C, Conley ME, Plebani A, Kumararatne DS, Bonnet D, Tournilhac O, Tchernia G, Steiniger B, Staudt LM, Casanova JL, Reynaud CA, Weill JC. Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire. Blood. 2004;104:3647-54.

    Therapeutic

    To our knowledge, no therapy targeting CD1c has been approved.


  • GENE_NAME : CD1C

    CD_NAME : CD1c

    GENERAL_INFORMATION

    NCBI_NAME CD1C
    NCBI_OTHER_NAME CD1
    SWISS_NAMES CD1C_HUMAN
    DESC CD1C antigen; c polypeptide

    LOCUS_INFO_LINKS

    HGNC_LOCUS_TAG: 1636
    ONLINE_MENDELIAN_INHERITANCE: 188340
    NCBI_HOMOLOGENE: 48040
    NCBI_MAP: 1q22-q23
    NCBI_ENTRE_GENE_ENTRY: 911
    GENE_SIZE: 3604
    EN_GE_EN:
    MRNA_SEQ_LENGTH: 1207
    PRCORENC: 52 to 1053
    ENTREN: ENST00000368170
    PROTEIN_LENGTH_NCBI_REFSEQ: 334
    NCBI_REF_SEF_ENTRY: NP_001756 , 4502647
    PROTEIN_LENGTH_SWISPROT: 333
    ENSEMBLE_PROT_ENTRY: ENSP00000357152
    PR_MO_WEIGHT: 37594
    SWPROT_PROTEIN_ENTRY: CD1C_HUMAN , P29017
    PR_SW_PR: 5.80
    IPI_NUMBER: IPI00019850
    NCBI_CONSV_DOMAINS: 4502647
    ENSM_NUMBER: P29017

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